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We are a biopharmaceutical company developing small molecule therapeutics derived from our boron chemistry platform
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AN2690


1  

Inhibition of Experimental Periodontitis by a Topical Boron-based Antimicrobial

Q. Luan, T. Desta, L. Chehab, V.J. Sanders, J. Plattner and D.T. Graves.

J Dent Res 87(2) 2008.


2

In Vitro penetration of a novel oxaborole antifungal (AN2690) into the human nail plate

Hui X, Baker SJ, Wester RC, Barbadillo S, Cashmore AK, Sanders V, Hold KM, Akama T, Zhang YK, Plattner JJ, Maibach HI.

J Pharm Sci., 2007 Jul 9.


3

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site

Rock FL, Mao W, Yaremchuk A, Tukalo M, Crepin T, Zhou H, Zhang YK, Hernandez V, Akama T, Baker SJ, Plattner JJ, Shapiro L, Martinis SA, Benkovic SJ, Cusack S, Alley MRK.

Science., 2007 Jun 22, 316(5832):1759-61.


4

Recent progress on the topical therapy of onychomycosis

Alley MRK, Baker SJ, Beutner KR, Plattner J.

Expert Opin Investig Drugs., 2007 Feb, 16(2):157-67.


5

Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases

Baker, S.J.; Akama, T.; Zhang, Y.K; Sauro, V.; Pandit, C.; Singh, R.; Kully, M.; Khan, J.; Plattner, J.J.; Benkovic, S.J.; Lee, V.; Maples K.R.

Bioorg. Med. Chem. Lett., 2006 Dec 1, 16(23):5963-7.


6

Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis

Baker, S.J.; Zhang, Y.K.; Akama, T.; Lau, A.; Zhou, H.; Hernandez, V.; Mao, W.; Alley, M.R.K.; Sanders, V.; Plattner, J.J.

J. Med. Chem., 2006, 49(15), 4447-4450.


7

Identification of Borinic Esters as Inhibitors of Bacterial Cell Growth and Bacterial Methyltransferases, CcrM and MenH

Benkovic, S.J.; Baker, S.J.; Alley, M.R.K.; Woo, Y.H.; Zhang, Y.K.; Akama, T.; Mao, W.; Baboval, J.; Rajagopalan, P.T.R.; Wall, M.; Kahng, L.S.; Tavassoli, A.; Shapiro, L.

J. Med. Chem., 2005, 48(23), 7468-7476.


8

Progress on New Therapeutics for Fungal Nail Infections

Baker, S.J; Hui, X.; Maibach, H.I.

Annual Reports in Medicinal Chemistry, 2005, 40, 323-334.


9

Mechanism-Based Inhibition of an Essential Bacterial Adenine DNA Methyltransferase: Rationally Designed Antibiotics

Wahnon, D.C.; Shier, V.K.; Benkovic, S.J.

J. Am. Chem. Soc., 2001, 123, 976-977.


 

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