Synthesis and evaluation of novel a-amino cyclic boronates as inhibitors of HCV NS3 protease

Xianfeng Li, Yong-Kang Zhang, Yang Liu, Charles Z. Ding, Qun Li, Yasheen Zhou, Jacob J. Plattner, Stephen J. Baker, Xuelei Qian, Dazhong Fan, Liang Liao, Zhi-Jie Ni, Gemma V. White, Jackie E. Mordaunt, Linos X. Lazarides, Martin J. Slater, Richard L. Jarvest, Pia Thommes, Malcolm Ellis, Colin M. Edge, Julia A. Hubbard, Don Somers, Paul Rowland, Pamela Nassau, Bill McDowell, Tadeusz J. Skarzynski, Wieslaw M. Kazmierski, Richard M. Grimes, Lois L. Wright, Gary K. Smith, Wuxin Zou, Jon Wright, Lewis E. Pennicott

Bioorganic & Medicinal Chemistry Letters 20 (2010) 3550-3556.

The novel sensitive and high throughput determination of cefepime in mouse plasma by SCX-LC/MS/MS method following off-line µElution 96-well solid-phase extraction to support systemic antibiotic programs

Bu W, Sexton H, Fan X, Torres P, Houston P, Heyman I, Liu L

Journal of Chromatography B, 878 (2010) 1623-1628.

Design and Synthesis of Boron-Containing PDE4 Inhibitors Using Soft-Drug Strategy for Potential Dermatologic Anti-Inflammatory Application

Zhang YK, Plattner J, Akama T, Baker SJ, Hernandez VS, Sanders V, Freund Y, Kimura R, Bu W, Hold K, Lu XS

Bioorganic & Medicinal Chemistry Letters 20 (2010) 2270-2274.

Therapeutic potential of boron-containing compounds

Baker SJ, Ding CZ, Akama T, Zhang YK, Hernandez V and Xia Y.

Future Med. Chem. (2009) 1(7), 1275-1288.

A direct LC/MS/MS method for the determination of ciclopirox penetration across human nail plate in in vitro penetration studies

Wei Bu, Xiaoqing Fan, Holly Sexton and Irwin Heyman

Journal of Pharmaceutical and Biomedical Analysis 51 (2010) 230–235.

Crystal Structures of the Human and Fungal Cytosolic Leucyl-tRNA Synthetase Editing Domains: A Structural Basis for the Rational Design of Antifungal Benzoxaboroles

Seiradake E, Mao W, Hernandez V, Baker S, Plattner J, Alley M and Cusack, S.,

Journal of Molecular Biology 390 (2009) 196-207.

Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis.

Akama T, Baker SJ, Zhang YK, Hernandez V, Zhou H, Sanders V, Freund Y, Kimura R, Maples KR and Plattner JJ.

Bioorganic & Medicinal Chemistry Letter 19 (2009) 2129-2132.

Inhibition of Experimental Periodontitis by a Topical Boron-based Antimicrobial

Q. Luan, T. Desta, L. Chehab, V.J. Sanders, J. Plattner and D.T. Graves.

J Dent Res 87(2) 2008.

Synthesis of isotopically labeled (3-¹⁴C) – and (3,3-²H₂) – 5 – fluoro – 1,3 – dihydro – 1- hydroxy-2,1- benzoxaborole (AN2690), a new antifungal agent for the potential treatment of onychomycosis.

Baker S, Zhang YK, Akama T, Wheeler C, Plattner J, Rosser R, Reid R and Nixon N.

Journal of Labelled Compounds and Radiopharmaceuticals, 50 (2007) 245-250.

In Vitro penetration of a novel oxaborole antifungal (AN2690) into the human nail plate

Hui X, Baker SJ, Wester RC, Barbadillo S, Cashmore AK, Sanders V, Hold KM, Akama T, Zhang YK, Plattner JJ, Maibach HI.

J Pharm Sci., 2007 Jul 9.

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site

Rock FL, Mao W, Yaremchuk A, Tukalo M, Crepin T, Zhou H, Zhang YK, Hernandez V, Akama T, Baker SJ, Plattner JJ, Shapiro L, Martinis SA, Benkovic SJ, Cusack S, Alley MRK.

Science., 2007 Jun 22, 316(5832):1759-61.

Recent progress on the topical therapy of onychomycosis

Alley MRK, Baker SJ, Beutner KR, Plattner J.

Expert Opin Investig Drugs., 2007 Feb, 16(2):157-67.

Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases

Baker, S.J.; Akama, T.; Zhang, Y.K; Sauro, V.; Pandit, C.; Singh, R.; Kully, M.; Khan, J.; Plattner, J.J.; Benkovic, S.J.; Lee, V.; Maples K.R.

Bioorg. Med. Chem. Lett., 2006 Dec 1, 16(23):5963-7.

Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis

Baker, S.J.; Zhang, Y.K.; Akama, T.; Lau, A.; Zhou, H.; Hernandez, V.; Mao, W.; Alley, M.R.K.; Sanders, V.; Plattner, J.J.

J. Med. Chem., 2006, 49(15), 4447-4450.

Identification of Borinic Esters as Inhibitors of Bacterial Cell Growth and Bacterial Methyltransferases, CcrM and MenH

Benkovic, S.J.; Baker, S.J.; Alley, M.R.K.; Woo, Y.H.; Zhang, Y.K.; Akama, T.; Mao, W.; Baboval, J.; Rajagopalan, P.T.R.; Wall, M.; Kahng, L.S.; Tavassoli, A.; Shapiro, L.

J. Med. Chem., 2005, 48(23), 7468-7476.

Progress on New Therapeutics for Fungal Nail Infections

Baker, S.J; Hui, X.; Maibach, H.I.

Annual Reports in Medicinal Chemistry, 2005, 40, 323-334.

Mechanism-Based Inhibition of an Essential Bacterial Adenine DNA Methyltransferase: Rationally Designed Antibiotics

Wahnon, D.C.; Shier, V.K.; Benkovic, S.J.

J. Am. Chem. Soc., 2001, 123, 976-977.

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