In late 2007, we began discovery efforts to design an anti-inflammatory compound that can penetrate human fingernails with the goal of treating nail psoriasis. According to an article presented at the 13th Annual European Academy of Dermatology & Venereology Annual Meeting, it has been estimated that 80% of psoriasis patients will have nail psoriasis at some time during their lives. The resulting changes to the nail caused by psoriasis not only affect the appearance of the nail, but also may cause pain or prevent the nail from functioning properly. If our efforts to design such a compound are successful, we currently intend to perform preclinical studies, followed by clinical trials, to study the efficacy and safety of the compound in treating nail psoriasis.