Back to Anacor Homepage Developing Drug Candidates Through Boron Chemistry
Infinite Menus, Copyright 2006, OpenCube Inc. All Rights Reserved.
  Boron Technology Overview

All of our current research and development programs have been internally discovered using our boron chemistry platform.

Our technology platform is based on the use of boron chemistry to develop novel therapies. Boron is a naturally occurring element that is ingested frequently through consumption of fruits, vegetables, milk and coffee. Boron has two attributes that we believe provide compounds with drug-like properties. First, boron based compounds have a unique geometry that allows them to have two distinct shapes, giving boron based drugs the ability to interact with biological targets in novel ways and can address targets not amenable to intervention by traditional carbon based compounds. Second, boronís reactivity allows boron based compounds to interact with a biological target to create a change that is specific to a particular disease or condition.

Despite the ubiquity of boron in the environment, researchers have faced challenges in evaluating boron-based compounds as product candidates due to previously limited understanding of the physical properties necessary to provide boron-based compounds with the chemical and biological attributes required of pharmaceutical therapies as well as difficulty in chemical synthesis.

We have developed expertise and an understanding of the interactions of boron-based compounds with key biological targets relevant to treating disease. This know-how is primarily related to methods for modulating boronís reactivity to optimize reactions with the target and minimize unwanted chemical reactivity. Our advances have enabled the efficient optimization of disease-modifying properties for our lead compounds and their rapid progression from the research stage into clinical trials.

Additionally, we have discovered new methods of synthesis of boron compounds, allowing for the creation of new compound families with broad chemical diversity and retention of drug-like properties. These new compound families expand the universe of biological targets that can be addressed by small molecule, boron based compounds.

We believe our focus on boron based chemistry provides us with multiple advantages in the small molecule drug discovery process. These advantages include:

  • Novel access to biological targets. Due to the unique geometry and reactivity of boron based molecules, our boron based compounds are able to modulate existing biological targets and can address targets not amenable to intervention by traditional carbon based compounds. This may enable us to treat diseases that have not been effectively addressed by carbon based compounds and develop antibiotic or antifungal therapies that kill pathogens that have become resistant to existing drugs.
  • Broad utility across multiple disease areas.Our compounds have exhibited extensive preclinical activity in multiple disease areas, including fungal, inflammatory and bacterial diseases, which are our core areas of focus, as well as in parasitic, diabetes, cancer and ophthalmic indications and applications in animal health.
  • Rapid and efficient synthesis of drug-like compounds. Our recent proprietary technological advances in the synthesis of boron based compounds coupled with our rational drug design capabilities have enabled us to rapidly create large families of boron based compounds with drug-like properties. These advances have made manufacturing of boron based compounds feasible on a commercial scale.
  • Unencumbered intellectual property landscape. We believe the intellectual property landscape for boron based pharmaceutical products is relatively unencumbered compared to that of carbon based products, providing an attractive opportunity for us to build our intellectual property portfolio.

  • We believe the unique characteristics of boron allow us to engineer novel product candidates that target a broad range of diseases and drive a rapid and efficient drug development process. Careers
    Learn more about Kerydin
    Learn more about AN2728