Back to Anacor Homepage Developing Drug Candidates Through Boron Chemistry
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  Overview | AN2690 | AN2718 | AN2728 | AN2898 | Nail Psoriasis | AN0128 | Systemic Anti-Infectives | Clinical Trials
    Pipeline - AN0128

We believe the unique characteristics of boron allow us to engineer novel product candidates that target a broad range of diseases and drive a rapid and efficient drug development process. Careers
AN2690

 
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Overview  

Our product candidate, AN0128, combines antibiotic properties with significant anti-inflammatory activity. We believe that this combination of antibiotic and anti-inflammatory properties gives AN0128 the potential to treat a number of indications, including gingivitis and acne.

AN0128's anti-inflammatory properties are a result of inhibition of pro-inflammatory cytokines, including TNF-alpha. In preclinical studies AN0128 has demonstrated antimicrobial activity against bacteria involved in gingivitis and shown effectiveness against bacteria in biofilms, which are generally difficult to treat. In addition, AN0128 reduced gingival inflammation in animal studies. AN0128 has also demonstrated activity in in vitro studies against antibiotic resistant strains of bacteria and other bacteria commonly found in the skin, and demonstrated inflammation-reducing activity similar to corticosteroids in animal models of inflammation.

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